ABSTRACT
Objective: This is an investigative study to evaluate a new companion diagnostic platform, allele specific multiplex sequencing
(ASMS). Detection of Braf p.V600E from solid tumors is used as the test model with the following objectives: 1) whether ASMS
can detect Braf p.V600E/K mutations from a variety of solid tumors, 2) whether ASMS can detect all Braf p.V600E from samples
that were positive for Braf V600E by SNaPshot or Ion Torrent, and 3) whether ASMS can detect Braf p.V600E among samples
that were reported negative by SNaPshot or Ion Torrent. Read full article